Dr. Wibool Piyawattanametha

Research Interests:

  • Advanced light microscopy and endoscopy for cancer diagnosis and treatment
  • Low-cost and portable diagnosis device for low resource settings
  • 3D optical image mapping for hallow organs in human
  • Deep learning for disease diagnosis
  • Portable environment diagnostic such as E. coli, coliforms, etc.

 

Brief Biography

Dr. Piyawattanametha received Ph.D. degree in Electrical Engineering from the University of California, Los Angeles, USA in 2004. From 2005 to 2009, he was with the Bio-X Program, Stanford University, Stanford, CA, USA as a senior scientist and later become a research associate in 2010. From 2010-2014, he worked as a senior research scientist at the National Electronics and Computer Technology Center, Thailand. Currently, he is with the King Mongkut’s Institute of Technology Ladkrabang, Ladkrabang, Thailand as the Director of Advanced Imaging Research (AIR) Center. He has authored or co-authored over 150 peer-reviewed publications, has contributed 8 book chapters and 4 patents in areas of Microelectromechanical Systems (MEMS), Photonics, and Biomedical Imaging. His h-index is 23.  He serves as the technical program chairs and organizing chairs for the Society of Photo-Optical Instrumentation Engineers (SPIE) in Optical MEMS and Miniaturized Systems of Photonics West Conference, USA; International Conference on Bioinformatics and Biomedical Engineering (iCBBE), USA; the Institute of Electrical and Electronics Engineers (IEEE) Optical MEMS and Nanophotonics, USA; IEEE CYBER, USA; IEEE Nanoelectromechanical Systems (NEMS); and IEEE Nanomedicine (NANOMED), USA. In 2010, he co-founded and served as an executive member of the Global Young Academy (GYA) based in Berlin, Germany. The GYA represents of the voice of young scientists around the world. In addition, he serves as a co-editor of the SPIE Micro/Nanolithography, MEMS, and MOEMS. In 2013, he was selected by the World Economic Forum (WEF), Switzerland to be one of the 40 top young scientists under the age of 40 who plays transformation role in integrating scientific knowledge and technological innovation to improve the state of the world. In 2014, he was one of the two recipients in the world to receive the prestigious Fraunhofer-Bessel Research Award from the Alexander von Humboldt Foundation, Germany for his pioneering work in light microendoscopy techniques. He is the first Thai scientist to receive this prestigious award. In 2015, he was awarded the Newton Fund Researcher Links from the British Council, United Kingdom for his novel optical imaging technique for early cancer detection. In 2017, he was selected to be a fellow in Leaders in Innovation Fellowships (LIF) from The Royal Academy of Engineering, United Kingdom.

Education

  • 2000 – 2004 D. in Electrical Engineering, University of California, Los Angeles, USA
  • 1997 – 1999 Sc. in Electrical Engineering, University of California, Los Angeles, USA
  • 1990 – 1994 Eng in Electronics Engineering, King Mongkut’s Institute of Technology Ladkrabang, Thailand

Employment History

  • 2014-present Technology consultant, Fraunhofer IPMS, Dresden, Germany and Biomedical Engineering Faculty Member, King Mongkut’s Institute of Technology Ladkrabang
  • 2010-2014 Group Leader, National Electronics and Computer Technology Center, Thailand and Director of Advanced Imaging Research Center, Faculty of Medicine, Chulalongkorn University, Thailand
  • 2007-2009 Physical Science Research Associate, Stanford University, USA
  • 2005-2006 Post-doctoral Research Scholar, Stanford University, USA
  • 1997-2004 Graduate Student Researcher, University of California, Los Angeles, USA
  • 1994-1997 Schlumberger Limited, France

Selected Publications

  1. Qiu and W. Piyawattanametha, “New Endoscopic Imaging Technology Based on MEMS Sensors and Actuators,” Micromachines 2017, 8(7), 210; doi:10.3390/mi8070210.
  2. Qiu and W. Piyawattanametha, “MEMS-Based Medical Endomicroscopes,” Journal of Selected Topics in Quantum Electronics (JSTQE), Vol.21, No.4, August 16, 2015, DOI 10.1109/JSTQE.2015.2389530.
  3. Khemthongcharoen, A. Ruangpracha, P. Sarapukdee, S. Rattanavarin, R. Jolivot, U. Jarujareet, K. Plaimas, P. Bhattarakosol, S. Patumraj, and W. Piyawattanametha, “Novel p16 binding peptide development for p16-overexpressing cancer cell detection using phage display,” Journal of Peptide Science, Vol. 21, Issue 4, April 2015, pp. 265-273.
  4. Qiu and W. Piyawattanametha, “MEMS based fiber optical microendoscopes,” Displays, Vol. 37, April 2015, pp 41-53.
  5. B. Wong, B. Y. Khoo, S. Sasidharan, W. Piyawattanametha, S. Kim, N. Khemthongcharoen, M. Y. Ang, L. O. Chuah, and M. T. Liong, “Inhibition of Staphylococcus aureus by crude and fractionated extract from lactic acid bacteria,” Beneficial Microbes, March 2015, 1;6(1):129-39.
  6. Zhao, Y. K. Lee, R Xu, C. Liang C, D. Y. Liu, W. Ma, W. Piyawattanametha, Y. Zohar, “Isolation of circulating tumor cells under hydrodynamic loading using microfluidic technology,” Advances in Mechanics, 2014, 44: 201412.
  7. Khemthongcharoen, S. Rattanavarin, R. Jolivot, and W. Piyawattanametha, “Advances in imaging probes and optical microendoscopic imaging techniques for early in vivo cancer assessment (invited paper),” Journal of Advanced Drug Delivery Reviews, July 30, 2014, Vol. 74, pp. 53-74.
  8. Kongsmak, P. Pungpit, M. R. Kano, S. Komai, W. Piyawattanametha, and O. Phanraksa, “Perceptions of Research Excellence in Thailand and Japan,” Science Technology and Innovation Policy Review, ISSN: 2093-3053, October 2013, Vol. 4, No. 2.
  9. Piyawattanametha, H. Ra, Z. Qiu, S. Friedland, J. T. C. Liu, K. Loewke, G. S. Kino, O. Solgaard, T. D. Wang, M. J. Mandella, and C. H. Contag, “In Vivo Near-infrared Dual-Axis Confocal Microendoscopy in the Human Lower Gastrointestinal Tract,” Journal of Biomedical Optics 17(2), February 2012, 021102:1-4.
  10. L. Hoy, O. Ferhanoglu, M. Yildirim, W. Piyawattanametha, H. Ra, O. Solgaard, and A. Ben-Yakar, “Optical design and imaging performance testing of a 9.6-mm diameter femtosecond laser microsurgery probe,” Optics Express 19, 10536 – 10552 (2011).
  11. Loewke, D. Camarillo, W. Piyawattanametha, M. J. Mandella, C. H. Contag, S. Thurn, and K. Salisbury, “In Vivo Micro-Image Mosaicing,” The IEEE Transactions on Biomedical Engineering, January 2011, Vol. 58, No. 1, pp. 159-171.
  12. Piyawattanametha, H. Ra, E. Gonzalez, M. J. Mandella, G. S. Kino, O. Solgaard, D. Leake, R. L. Kaspar, A. Oro, and C. H. Contag, “In vivo imaging of human and mouse skin with a dual-axis confocal fluorescence microscope,” Journal of Investigative Dermatology, January 2011, 131, 1061-1066.
  13. T. C. Liu, M. J. Mandella, N. O. Loewke, H. Haeberle, H. Ra, W. Piyawattanametha, O. Solgaard, G. S. Kino, and C. H. Contag, “Micromirror-scanned dual-axis confocal microscope utilizing a gradient-index relay lens for image guidance during brain surgery,” Journal of Biomedical Optics, Aril 2010, vol. 15, pp. 026029.
  14. Piyawattanametha and T. D. Wang, “MEMS-Based Dual Axes Confocal Microendoscopy (Invited Paper),” The IEEE Journal of Selected Topics in Quantum Electronics (JSTQE), July-August 2010, Vol. 16, Issue 4, pp. 804-814.
  15. Piyawattanametha, H. Ra, M. J. Mandella, K. Loewke, T. D. Wang, G. S. Kino, O. Solgaard, and C. H. Contag, “3-D Near Infrared Fluorescence Imaging using a MEMS-based Miniature Dual-Axes Confocal Microscope,” The IEEE Journal of Selected Topics in Quantum Electronics (JSTQE), Sept-Oct 2009, Vol. 15, Issue 5, pp. 1344-1350.
  16. Piyawattanametha, et al., “MEMS microscope images brain,” Nature Photonics, Vol. 3, November 2009, pp. 622-623.
  17. Piyawattanametha, E. D. Cocker, L. D. Burns, R. P. J. Barretto, J. C. Jung, H. Ra, O. Solgaard, and M. J. Schnitzer, “In vivo brain imaging using a portable 2.9 gram two-photon microscope based on a microelectromechanical systems scanning mirror,” Optics Letters, August 1, 2009, Vol. 34, No. 15, pp. 2309-2311.
  18. Gonzalez, H. Ra, R. P. Hickerson, Q. Wang, W. Piyawattanametha, M. J. Mandella, G. S. Kino, D. Leake, A. A. Avilion, O. Solgaard, T. C. Doyle, C. H. Contag, and R. L. Kaspar, “siRNA silencing of keratinocyte-specific GFP expression in a transgenic mouse skin model,” Gene Therapy (2009), Vol. 16, May 28, 2009, pp. 963-972.
  19. Gonzalez, H. Ra, R. P. Hickerson, Q. Wang, W. Piyawattanametha, M. J. Mandella, G. S. Kino, D. Leake, A. A. Avilion, O. Solgaard, T. C. Doyle, C. H. Contag, and R. L. Kaspar, “Characterization of a transgenic GFP mouse skin model for development of siRNA delivery technologies,” Journal of Investigative Dermatology, April 2009, 129, S90.
  20. L. Hoy, N. J. Durr, P. Chen, W. Piyawattanametha, H. Ra, O. Solgaard, and A. Ben-Yakar, “Miniaturized probe for femtosecond laser microsurgery and two-photon imaging,” Optics Express, Vol. 16 (2008), Issue 13, pp. 9996-10005.
  21. Ra, W. Piyawattanametha, M. J. Mandella, P. L. Hsiung, J. Hardy, T. D. Wang, C. H. Contag, G. S. Kino, and O. Solgaard, “Three-dimensional in vivo imaging by a handheld dual-axes confocal microscope,” Optics Express, Vol. 16 (2008), Issue 10, pp. 7224-7232.
  22. Harald and W. Piyawattanametha, “Silicon-based MOEMS and their applications,” JOURNAL OF MICRO-NANOLITHOGRAPHY MEMS AND MOEMS  Volume: 7   Issue: 2     Article Number: 020901   DOI: 10.1117/1.2913329   Published: APR-JUN 2008.
  23. Ra, W. Piyawattanametha, Y. Taguchi, D. Lee, M. J. Mandella, G. S. Kino, C. H. Contag, and O. Solgaard, “Two-dimensional MEMS scanner for dual-axes confocal microscopy,” IEEE Journal of Micro Electromechanical Systems (JMEMS), Vol. 16, August 2007, pp. 969-976.
  24. D. Aguirre, P. R. Herz, Y. Chen, J. G. Fujimoto, W. Piyawattanametha, L. Fan, and M. C. Wu, “Two-axis MEMS Scanning Catheter for Ultrahigh Resolution Three-dimensional and En Face Imaging,” Optics Express, Vol. 15 (2007), Issue 5, pp. 2445-2453.
  25. D. Cocker, B. A. Flusberg, W. Piyawattanametha, J. C. Jung, R. P. J. Baretto, T. H. Ko, H. Ra, D. Lee, O. Solgaard, and M. J. Schnitzer, “Portable forms of fiber-optic one- and two-photon fluorescence microendoscopy towards imaging in freely moving mice,” Biophys. J., 154A-154A (2007).
  26. T. C. Liu, M. J. Mandella, H. Ra, L. K. Wong, P. Hsiung, T. D. Wang, G. S. Kino, W. Piyawattanametha, C. H. Contag, and O. Solgaard, “A miniature near-infrared dual-axes confocal microscope utilizing a two-dimensional MEMS scanner,” Optics Letters: Vol. 32 (2006), Issue 3, pp. 256-258.
  27. Piyawattanametha, R. P. J. Barretto, T. H. Ko, B. A. Flusberg, E. D. Cocker, H. Ra, D. Lee, O. Solgaard, and M. J. Schnitzer, “Fast-scanning two-photon fluorescence imaging based on a microelectromechanical systems two-dimensional scanning mirror,” Optics Letters, Vol. 31, No. 12, July 1, 2006, pp. 2018-2020.
  28. A. Flusberg, E. D. Cocker, W. Piyawattanametha, J. C Jung, E. L. M. Cheung, and M. J. Schnitzer, “Fiber-optic Fluorescence Imaging (Invited Paper),” Nature Methods: 2, 941 – 950 (2005).
  29. Piyawattanametha, P. Patterson, D. Hah, H. Toshiyoshi, and M. C. Wu, “Surface- and Bulk- Micromachined Two Dimensional Scanner Driven by Angular Vertical Comb Actuators,” IEEE Journal of Micro Electromechanical Systems (JMEMS), Vol. 14,  Issue 6,  December 2005, pp.1329 – 1338.
  30. Fujino, Pamela R. Patterson, H. Nguyen, W. Piyawattanametha, and M. C. Wu, “Monolithically Cascaded Micromirror Pair Driven by Angular Vertical Combs for Two-Axis Scanning,” IEEE Journal on Selected Topics in Quantum Electronics, Vol. 10, No. 3, May/June 2004, pp. 492-497.
  31. Nguyen, D. Hah, P. R. Patterson, R. Chao, W. Piyawattanametha, and M. C. Wu, “Angular Vertical Comb Driven Tunable Capacitor with High Tuning Capabilities,” IEEE Journal of Micro Electromechanical Systems (JMEMS), June 2004, Vol. 3, No. 3, pp. 406-413.
  32. Toshiyoshi, W. Piyawattanametha, C. -T. Chan, and M. C. Wu, “Linearization of Electrostatically Actuated Surface Micromachined 2-D Optical Scanner,” IEEE Journal of Microelectromechanical Systems (JMEMS), June 2001, Vol. 10, No. 2, pp. 205-214.